http://www.bdtd.uerj.br/handle/1/18049 2026-05-11T21:54:14Z http://www.bdtd.uerj.br/handle/1/25610 Título: Avaliação da atividade antibacteriana e estudo químico de extratos aquosos de Rhizophora mangle coletada em três regiões da Reserva Biológica Estadual de Guaratiba Autor: Peixoto, João Vitor Braga Alves Primeiro orientador: Fingolo, Catharina Eccard Abstract: Mangroves are coastal ecosystems found in tropical and subtropical regions worldwide. They play a crucial role in maintaining marine and terrestrial biodiversity, serving as nurseries for fish, crustaceans, and birds, as well as acting as natural barriers against erosion and extreme climatic events. The plants that inhabit this environment exhibit adaptations to salinity and flooding conditions, resulting in the production of a wide variety of secondary metabolites. These chemical constituents are essential for defense against pathogens and predators, and many of them exhibit therapeutic potential due to their antioxidant, antimicrobial, anti inflammatory, and anticancer properties. In recent years, the increasing number of infections caused by antibiotic-resistant bacteria has become a public health concern, encouraging the search for new therapeutic sources. In this context, the present study aimed to evaluate the antibacterial activity of aqueous extracts from the leaves of Rhizophora mangle collected from the Guaratiba State Biological Reserve using a litterfall system, as well as to chemically characterize these extracts by High-Performance Liquid Chromatography coupled with High Resolution Tandem Mass Spectrometry (HPLC-HRMS/MS). Antibacterial activity was assessed using the well-diffusion and drop-diffusion methods in order to evaluate the effectiveness of the extracts against different Gram-positive and Gram-negative bacterial strains. The aqueous extracts exhibited antibacterial activity against Staphylococcus aureus, including when compared to the tested Gram-negative strains. Inhibition halos ranging from 22.0 to 27.0 mm were observed at concentrations between 6.67 and 20% (m/v), values higher than those obtained for the positive control (19.0 mm), indicating greater efficacy of the extracts. Chemical analysis by HPLC-HRMS/MS revealed the presence of several secondary metabolites, including flavonoids, phenols, and organic acids, which are known for their bioactive properties. These results demonstrate that the identified components may be associated with the observed antibacterial activity, suggesting that the extracts represent a promising source for the development of phytotherapeutic agents. Furthermore, the findings contribute to the understanding of the pharmacological potential of mangrove plants and highlight the importance of conserving these ecosystems, which constitute reservoirs of natural substances that remain largely unexplored. Instituição: Universidade do Estado do Rio de Janeiro Tipo do documento: Dissertação 2025-11-25T00:00:00Z http://www.bdtd.uerj.br/handle/1/25605 Título: Proposta de criação de uma farmácia escola no campus Zona Oeste da Universidade do Estado do Rio de Janeiro com ênfase na conscientização ambiental Autor: Carmo, Alan Pereira do Primeiro orientador: Vieira, Jessica Manya Bittencourt Dias Abstract: The present work is a proposal to create a pharmacy school at the University of State of Rio de Janeiro, Campus Zona Oeste with the objetive of to contribute to the training of students and professionals in order to provide services and inform the population around the university with an emphasis on environmental awareness. Bibliographic research of scientific articles, publications of technical papers, municipal, state and federal legislation, resolutions, technical notes and academic publications were carried out. The research carried out demonstrated the concern of the Federal Council of Pharmacy - CFF with the quality of student training, thus considering the importance of the school pharmacy at this crucial moment in the academic and professional life of future pharmacists. The services provided at the school pharmacy allow students to have a closer contact with the reality of pharmaceutical professionals in serving the public. It expands the population's access to the pharmaceutical professional, allowing clarification on the importance of the correct use of the medication, from the moment of acquisition to the moment of disposal, the importance of correctly disposing of "leftovers" of medicines or expired medicines, demonstrating the importance care for the environment, avoiding pollution with emerging contaminants, minimizing the effects caused by these pollutants, aiming at improving the population's quality of life. Research has shown that a large part of the students of the courses aimed at patient care and a good part of the professionals working in the health units are unaware of the correct procedures for the proper disposal of medicines, the proposal to create the school pharmacy aims to contribute to the training of these professionals and in public awareness. Instituição: Universidade do Estado do Rio de Janeiro Tipo do documento: Dissertação 2022-05-05T00:00:00Z http://www.bdtd.uerj.br/handle/1/24459 Título: Avaliação do nível de radioatividade natural da região da futura APA Municipal Ilha Verde, Muriqui, Mangaratiba - RJ Autor: Pinheiro, Rodrigo de Barros Primeiro orientador: Souza, Edmilson Monteiro de Abstract: The project for the creation of the Municipal Environmental Protection Area (APA) Ilha Verde in 2024 aims primarily to transform an area that once functioned as a quarry into a space for environmental preservation, sustainability, and recreation for the residents of Muriqui, the 4th district of Mangaratiba, thereby promoting ecotourism in the locality. Considering the presence of rocky outcrops in the region, which are part of the geological context of Granito Serra do Piloto, and that these have been described in the literature as sources of natural radioactivity due to their mineralogical composition, it becomes essential to analyze the natural background radiation of the area and the potential radiation dose to which visitors and workers of this APA may be exposed. In light of the above, given that the consequences of prolonged exposure to ionizing radiation on human health are extremely harmful, this study aims to conduct a radiometric survey to investigate the gamma background radiation levels at distinct and specific points within the area where the APA will be established. The in situ measurement of gamma background radiation levels was carried out using a portable nuclear radiation detector of the Geiger-Müller type, model GQ GMC 500+, properly calibrated, at an elevation of approximately 1 meter above ground level. A Global Positioning System (GPS) was utilized to identify the geographical positions throughout the analyzed region. A total of 17 points were analyzed across the study area for gamma background radiation. The measured values of average absorbed dose rates of gamma background radiation varied from 0.14 ± 0.025 μSv/h to 0.20 ± 0.027 μSv/h, with an overall mean value of 0.17 μSv/h ± 0.021 μSv/h. These values were used to assess the radiological risk arising from radiation at the measurement sites through calculations of annual effective dose equivalent rates, the lifetime excess cancer risk, and the effective dose to various organs of the body. Thus, by comparing the values obtained from measurements at the different points in the region and the calculations described earlier with the limits established by legislation, it was concluded that the region does not pose immediate radiological risks to the health of visitors and workers in the future APA. Instituição: Universidade do Estado do Rio de Janeiro Tipo do documento: Dissertação 2025-07-23T00:00:00Z http://www.bdtd.uerj.br/handle/1/24109 Título: Contextualização do projeto de implantação de hidrovia no Complexo Lagunar de Jacarepaguá – RJ: ondas geradas pelas embarcações Autor: Teixeira, Mariana Brito Primeiro orientador: Oliveira, Maria Francisca do Nascimento Abstract: This study proposes to contextualize the waterway implementation project in the Lagoon Complex of Jacarepaguá – RJ and analyze the proposed geometry and efficiency from the point of view of the waves generated by the vessels. To estimate the possible hydraulic loads in the channel foreseen by the City Hall, the calculation script presented in PIANC n˚ 57 (1987) was used. The objective was to carry out a preliminary analysis of the dimensions of the proposed channel, considering the wave action of the vessel. In the study presented by the City Hall on the waves generated by vessels, the recommendation is that in places where navigation is restricted in width and depth, speeds should be controlled by the nautical authorities. However, it was observed that the effects caused by waves from vessels showed that the proposed speed is high regarding the limit values established in the literature. Instituição: Universidade do Estado do Rio de Janeiro Tipo do documento: Dissertação 2023-06-26T00:00:00Z