TEDE Coleção:
http://www.bdtd.uerj.br/handle/1/3566
2024-03-29T12:05:12ZMedicina endodôntica: associação entre desordens sistêmicas ou hábitos deletérios e a periodontite apical
http://www.bdtd.uerj.br/handle/1/21631
Título: Medicina endodôntica: associação entre desordens sistêmicas ou hábitos deletérios e a periodontite apical
Autor: Pinto, Karem Paula
Primeiro orientador: Sassone, Luciana Moura
Abstract: The endodontic medicine assesses the bidirectional relationship between systemic disorders and apical periodontitis. There is evidence that both apical periodontitis can influence systemic changes, as the opposite. However, there is a need to clarify the mechanisms involved in this relationship. This thesis was divided into two studies seeking to evaluate the metabolic alterations that may be involved in the association between systemic disorders or deleterious habits and apical periodontitis and to carefully review the existing literature. The study 1 evaluated the periapical bone pattern and the serum levels of pro-inflammatory cytokines, biochemical markers and metabolites in rats submitted to chronic consumption of alcohol and/or nicotine and induction of apical periodontitis. Twenty-eight male Wistar rats were assigned to Control, Alcohol, Nicotine and Alcohol+Nicotine groups. The groups submitted to alcohol were exposed to self-administration of 25% alcohol solution and the groups submitted to nicotine received daily intraperitoneal injections of a solution with 0.19 μl of nicotine/mL. The pulps of the lower left first molars were exposed for 28 days to induce periapical lesions. After euthanasia, the mandibles were removed and the periapical bone was evaluated by microcomputed tomography images. Blood samples were collected and the serum samples were submitted to Luminex assay for measurement of pro-inflammatory cytokines, biochemical and metabolomic analyses. The groups submitted to alcohol or nicotine consumption showed altered bone patterns indicating lower bone density and higher levels of IL-1β, IL-6 and TNF-α, in relation to the Control group. Significant differences were also observed in the levels of several biochemical markers and metabolites. Most of these parameters were even more altered in the simultaneous consumption of both substances, compared to the single consumption. The study 2 evaluated the systematic reviews that assessed the association between apical periodontitis and chronic systemic diseases through an umbrella review. A systematic search was performed in PubMed, Virtual Health Library, Scopus, Cochrane Library, Embase, Web of Science and Open Gray databases. Nine studies that met the eligibility criteria were included. The AMSTAR-2 tool was used to assess the quality of each included systematic review, which showed “low” to “high” quality of evidence. There was a positive association between diabetes and apical periodontitis with limited evidence, no association between HIV and apical periodontitis, and a positive association between apical periodontitis and cardiovascular disease, blood disorders, chronic liver disease, osteoporosis and autoimmune diseases with moderate evidence. Based on the studies, it was concluded that systemic disorders can exacerbate inflammation in apical periodontitis, as periapical lesions can interfere with systemic diseases. The chronic consumption of alcohol or nicotine has harmful effects on apical periodontitis through the alteration of metabolic pathways that lead to an increase in the production of pro-inflammatory mediators, which was even more intense in the simultaneous consumption of both substances.
Instituição: Universidade do Estado do Rio de Janeiro
Tipo do documento: Tese2022-11-03T00:00:00ZComparação tridimensional dos movimentos ortodônticos de rotação, inclinação e angulação planejados e obtidos em dentes anteriores com alinhadores transparentes: um estudo retrospectivo
http://www.bdtd.uerj.br/handle/1/20923
Título: Comparação tridimensional dos movimentos ortodônticos de rotação, inclinação e angulação planejados e obtidos em dentes anteriores com alinhadores transparentes: um estudo retrospectivo
Autor: Casagrande, Caroline Pelagio Maués
Primeiro orientador: Carvalho, Felipe de Assis Ribeiro
Abstract: Removable transparent aligners are increasingly being used, and due to its popularity new companies are emerging in the market. Therefore, it is important to evaluate the movement accuracy of these devices. The aim of this study was to compare digitally planned orthodontic movements of rotation, vestibulolingual tip, and mesiodistal tip with the clinical movements obtained in anterior teeth using transparent orthodontic aligners from a Brazilian manufacturer (Smart Aligner®) in a three-dimensional manner. The sample size was calculated and the methodology was applied to 28 patients. It could be observed that for mesiodistal tip movements in the upper arch, the average error between the planned and obtained movements of each group ranged from 5.04° to 7.62°; in the lower arch, from 5.63° to 7.47°. For rotation movements in the upper arch, it ranged from 4.5° to 6.63°, and in the lower arch, from 5.84° to 6.56°. For vestibulolingual tip movements, in the upper arch it ranged from 2.81° to 3.01°, and in the lower arch from 2.55° to 3.58°. Using the Kruskal-Wallis test with Bonferroni correction to compare the movements performed, a statistically significant difference was detected between the planned and actually achieved movements in this sample. When comparing what was simulated with the obtained results, a statistically significant difference was observed only when comparing vestibulolingual tip with rotation and vestibulolingual tip with mesiodistal tip. There was no significant difference when comparing mesiodistal tip with rotation. It can be concluded that there is a difference between planned and obtained movements of rotation, vestibulolingual tip, and mesiodistal tip using transparent aligners. Despite the high average discrepancy between planned and obtained movements, the standard deviation showed a similar order of magnitude, indicating both positive and negative results. Among the movements studied, vestibulolingual tip was the movement that showed the most accurate results.
Instituição: Universidade do Estado do Rio de Janeiro
Tipo do documento: Tese2023-05-04T00:00:00ZComparação dos efeitos esqueléticos, alveolares e dentários após expansão rápida da maxila dento-suportada e dento-ósseo suportada em pacientes pós-surto de crescimento puberal: estudo feito a partir de medidas angulares
http://www.bdtd.uerj.br/handle/1/20362
Título: Comparação dos efeitos esqueléticos, alveolares e dentários após expansão rápida da maxila dento-suportada e dento-ósseo suportada em pacientes pós-surto de crescimento puberal: estudo feito a partir de medidas angulares
Autor: Fernandes, Luciana Quintanilha Pires
Primeiro orientador: Capelli Júnior, Jonas
Abstract: Rapid palatal expansion (RPE) is an auxiliary procedure in orthodontic treatment that aims to increase the transverse maxillary dimension, also providing a rotational movement of zygomaticomaxillary complex. The objective of this study is to evaluate the effects on maxillary base bone, on alveolar process of the maxilla and on upper first molars, through angular measurements, after conventional RPE with hyrax expander and with miniscrew-assisted rapid palatal expansion (MARPE), and identify the fulcrum of rotation after treatment with both techniques. For this purpose, 31 patients were selected (HYRAX group: n = 17, mean age 14.7 + 0.8 years; MARPE group: n = 14, mean age 16.2 + 2 years) with indication for RPE. Cone-beam computed tomography (CBCT) images were taken before treatment (T1), immediately after expansion (T2), and after a 6-month retention period (T3). The CBCT images were oriented and superimposed on the anterior cranial base using Dolphin Imaging software, so that the measurements of interest were randomly performed by the same examiner. The whole process of manipulating and measuring the CBCT images was performed twice in six patients, with an interval of 15 days, to assess method error. For statistical analysis, Jamovi software version 2.3.21 was used. The Intraclass Correlation Coefficient (ICC) was greater than 0.90 for all measures, demonstrating excellent replicability of the method. In the HYRAX group, the fulcrum of rotation was located at or below the frontozygomatic suture (FZS), while in the MARPE group the fulcrum was located at or above the FZS. In the HYRAX group, it was observed that 47% (1.54o) of the response obtained was of dental origin, 20% (0.68o) of alveolar origin and 33% (1.09o) of skeletal origin, while in the MARPE group the skeletal response was 70% (2o), alveolar response was 18% (0.52o) and dental response was 12% (0.34o), with a statistically significant difference between groups in the skeletal (p = 0.005) and dental (p < 0.001) regions. Regarding the retention phase, the HYRAX group had a relapse of 50% in skeletal region, 53% in alveolar region and 32% in dental region, while the MARPE group had a relapse of 41% in skeletal region, 27% in alveolar region and 28% in dental region, with no statistically significant difference between groups. In conclusion, although both techniques were efficient in correcting the initial transverse deficiency, with no difference regarding the stability of the results, the difference found between groups suggests that miniscrew-assisted rapid palatal expansion (MARPE) should be indicated for borderline cases, where minimum compensatory tooth movement is desired.
Instituição: Universidade do Estado do Rio de Janeiro
Tipo do documento: Tese2023-05-02T00:00:00ZLiberação dos fatores de crescimento TGF β1 e VEGF após condicionamento dentinário com agentes quelantes: análise ex vivo
http://www.bdtd.uerj.br/handle/1/20297
Título: Liberação dos fatores de crescimento TGF β1 e VEGF após condicionamento dentinário com agentes quelantes: análise ex vivo
Autor: Tomaz, Milena do Valle
Primeiro orientador: Sassone, Luciana Moura
Abstract: Growth factors sequestrated in dentin play an important role in the repair process of the dentino pulp complex. The aim of this study was to investigate, ex vivo, the release of growth factors TGFβ1 e VEGF, sequestrated in dentin, after conditioning with the chelating agents: EDTA, Chitosan and Etidronic Acid (HEBP). The smear layer removal and the dentin tubules erosion were also analysed. by SEM. A total of seventy two teeth met the following criteria: permanent teeth with single rooted teeth, without caries, fractures, resorption and/or previous endodontic treatment, were selected for the preparation of specimens. The crowns and the apical portion of teeth were removed and root segments were prepared to cylinder shape with 8 mm. The root segment was instrumented up to Gates Glidden size 4 to standardize the internal diameter at 1mm.Thirty six specimens were initially irrigated with 20 mL/5 min of NaOCL and then randomly assigned into four groups (n=9 for each group) with different final irrigation protocols: 17% EDTA (20mL/5 min); 0.2% Chitosan (20 mL/5 min); 9% HEBP (20 mL/ 5min); Saline (20 mL/5 min).After the final irrigation the specimens were kept in an 1,5mL Eppendorf microtubes containing α-MEM medium and 100 U/mL penicilin e 100 U/mL de estreptocimicin at 37°C for twenty four hours. After that time the medium from thirty six Eppendorf tubes were collected and the growth factors release was quantified using an immunoenzymatic test ELISA. The data were not submitted to any statistical test because the release of growth factors TGF β1 e VEGF was not detected in any tested group. Longitudinal grooves were made on the mesiodistal surfaces of another thirty six specimens using a low-speed diamond disk. Photomicrographs of the cervical, middle and apical thirds in order to compare the effectiveness of different chelating agents the smear layer removal and the degree of the dentinal tubules erosion, using electron microscopy (SEM). Data were submitted to the non- parametric tests Kruskal-Wallis and Dunn with a significance level of α = 0,05. The final irrigation protocols with the chelating agents EDTA 17%, Chitosan 0,2% and HEBP 9% was efficient in removing the smear layer and promote some erosion in the dentine tubules, with no significant difference between the tested groups. Based in the methodology employed and according to the results of this study ita can be concluded that: a) it was not possible to quantify the release of growth factors TGF β1 and VEGF with the ELISA kit used; b) As all the chelating agents tested were efficient in smearlayer removal and promote some degree of dentin tubules erosion, in all regions analysed, Chitosan 0,2% can be a natural substitute for EDTA 17%.
Instituição: Universidade do Estado do Rio de Janeiro
Tipo do documento: Tese2023-02-27T00:00:00Z