Efeito do tratamento periodontal nos níveis de osteocalcina sérica em pacientes com diabetes tipo 2 e periodontite crônica severa

Abstract

Bone tissue is metabolically active and undergoes a continuous process of resorption and formation. Osteocalcin is a peptide secreted by osteoblasts. Although primarily deposited in newly formed bone matrix, a small fraction enters into circulation in the bloodstream and is considered as a marker of bone formation and interferes with glucose homeostasis. The aim of this study was to investigate whether periodontal treatment affects serum osteocalcin levels in patients with type 2 diabetes and severe chronic periodontitis. 26 patients were divided into test group (n = 13, mean age 55.8 ± 8.4 years, 9 men and 4 women) and control. (n = 13, mean age 59.4 ± 8.4, 5 men and 8 women). The test group received periodontal treatment and untreated control group. Periodontal examination included PI measures (plaque index), BOP (bleeding on probing), PPD (probing pocket depth), CAL (clinical attachment level). Laboratory tests included HbA1c, glucose, triglyceride, total cholesterol and fractions. The concentration of serum osteocalcin was analyzed by ELISA. Periodontal examination, laboratory tests and concentration of osteocalcin were reassessed after 90 days. The results showed no significant changes in periodontal parameters, laboratory tests, and osteocalcin levels 90 days after periodontal treatment. In conclusion, periodontal treatment did not influence the serum levels of osteocalcin in patients with type 2 diabetes and severe chronic periodontitis.