Análise do Volume Plaquetário Médio (VPM) em pacientes com obesidade: a influência do EDTA após a coleta

Abstract

Mean platelet volume is an important marker of platelet reactivity. The increase in the level of VPM has been associated with numerous pathologies and, however, can be used as a risk biomarker in addition to monitoring patients that avoid future problems. Seeing hematological analyzers, this is a parameter as an integral part of the hemogram, but a series of factors can generate doubtful results and among them the action of the anticoagulant EDTA and time between a collection and analysis of the blood material due to this factor we sought to provide a view on an action of the time dependent EDTA relative to platelets and the MPV values. As a matter of obesity, a prevalence increases worldwide each year. Due to the clinical importance of platelets and mean platelet volume in obese patients, we compared the MPV of people with normal body mass index (BMI) with people with BMI in the overweight and obesity range. In this work we observed that in the first two hours after a collection of blood material there is a significant non-MPV increase. In addition, we observed that on average the overweight and obese group presented higher MPV values in relation to the control group, presenting approximately MPV of 7.4 fl overweight, 7.5 obese and 6.8 fl in the control group (p: <0.05). The increase in MPV can be observed when comparing the obese groups with the weight group in force, but quality protocols should be followed so that EDTA does not interfere with the MPV values