Sistemas catalíticos contendo Pd e amido para a obtenção de tiouréias com potencial medicinal

Abstract

The interest in the development of biaryl ureas/thioureas was focused on the possibility of novel pharmaceutical candidates. Ureas and thioureas can be consideredas special classes with worthy medicinal potential to several diseases - especially in virtue of a tuned lipophilicity as well as the presence of donators / aceptors sites of Hydrogen bonds. Therefore, synthetic strategies involving the formation of structural patterns can allow the discovery of novel structure-activity relationships. In view of the widespread importance of organometallic catalysis towards the formation of biaryls and related systems, the present work envisages the synthesis of novel compounds containing the ureido/ thioureido scaffolds by using metal-catalyzed carbon-carbon cross-coupling reactions, in this case palladium nanoparticles. A specific aim involves the use of environmentally friendly conditions (i.e. papaya waste valorization, aqueous medium, reductants/ stabilizers based on polyols). In the case of papaya waste valorization, BITC (benzylisothiocyanate), synthetic precursor of thiourea, can be extracted from the C. papaya seeds