Consequências da dieta rica em frutose parental, ou só materna, ou só paterna no metabolismo hepático da prole adulta de machos

Abstract

The study aimed to evaluate the consequences of feeding high-fructose diet (HFR) to mother or father, and to both mother and father, on progeny. Parents received HFR or control diet (C) for eight weeks before mating until weaning. After weaning, pups (identified first by the mother’s diet, then by the father’s diet) only received C diet until three months of age. Parents: blood pressure (BP) was higher in HFR parents, compared to their controls (father +27%, mother +35%, P < 0.0001). The HFR parents, had an enlarged liver (father +15%, mother +18%, P = 0.0290), greater hepatic triacylglycerol content (father +89%, mother +41%, P < 0.0001), hypercholesterolemia (father +25%, mother +24%, P = 0.0158), hypertriglyceridemia (father +45%, mother +39%, P < 0.001), higher plasmatic leptin and lower adiponectin (Leptin: father +68%, mother +55%, P < 0.0001; Adiponectin: father -6%, P = 0.018, mother -21%, P < 0.0001). Offspring: compared to C/C, HFR/HFR had high BP; C/HFR, HFR/C, and HFR/HFR showed higher uric acid and leptin, and lower adiponectin. HFR/HFR showed higher liver inflammation markers (NF?-B, SOCS3, JNK, TNF-alpha, IL1-beta, and IL-6). HFR/HFR showed an increase of both SREBPB1c and FAS. In conclusion, the study can demonstrate that both mother and father, individually, or in combination fed a HFR diet may affect the metabolism and liver in the adult male progeny. The combination of mother and father HFR enhanced the adverse effects on the offspring health and had other consequences in the offspring programming than the mother and father alone.