Comparação entre o uso do óleo de oliva e ácidos graxos em lesões cutânes agudas em camundongos

Abstract

Skin lesions can be a serious health problem due to the associated morbidity and high costs involved in their treatment. A commercial formulation rich in essential fatty acids and triglycerides is widely used to prevent and treat injuries, however, this formulation has a high cost, making access to this treatment difficult. However, it has already been shown that, in some situations, olive oil, which has a low cost, can promote skin repair by having antioxidant and anti-inflammatory properties. The hypothesis arises that olive oil is a product capable of assisting tissue repair, similar to a formulation rich in fatty acids. The aim of the study was to compare the effects of a commercial formulation rich in fatty acids with olive oil on the healing of acute lesions in mice. Male Swiss mice were randomly divided into 3 groups: control, olive oil and fatty acids, treated respectively with mineral oil, extra virgin olive oil and fatty acid solution. The lesions were performed on the mice's back and treated topically with the compounds. Six days after the injury, injuries treated with olive oil and fatty acids decreased compared to the control group. Olive oil decreased the amount of neutrophils. VEGF expression was increased in the olive oil and fatty acid groups. In addition, olive oil proved to be an antioxidant because it has a lower amount of ROS, nitrite and TBARS compared to the control group. With the results obtained it was possible to conclude that both the topical application of olive oil and a compound rich in fatty acids was able to improve the healing of acute lesions in mice