Níveis de marcadores inflamatórios na saliva de adolescentes com lúpus eritematoso sistêmico juvenil

Abstract

Objective: the aim of this study was to assess the levels of inflammatory markers in the saliva of teenagers with juvenile systemic lupus erythematosus (jSLE). Material and methods: 43 patients were selected to participate the study and were splited in 2 groups: jSLE (n=21) and sistemically healthy (n=22). All participants underwent to a gold standard periodontal examination and had their saliva collected. The rheumatologic data of jSLE patients were also collected. IL-34 analysis was determined by ELISA and the cytokines tumor necrosis factor alpha (TNF-), interferon gamma (IFN-), IL-23, IL-1 e IL-6 were analyzed by LUMINEX. Results: The jSLE group had a significantly higher clinical attachment loss (CAL) (p=0.001) than the sistemically healthy group. Both groups were similar regarding pocket depth, bleeding on probing and percentage of sites with plaque. There was no statistical difference between groups regarding the six cytokines analyzed. In the jSLE group, there was a positive correlation between IL-1 with CAL=1-2mm (p=0.042), TNF- with erythrocyte sedimentation rate (ESR) (p=0.041) and there was a tendency between IL-6 with body mass index (BMI) (p=0.050). Comparing jSLE subjects according to disease activity status, it was observed that IL-1 was significantly higher (p=0.025) in subjects in remission than in subjects with the disease in activity. Conclusion: Individuals with jSLE have more attachment loss than control individuals. The concentrations of inflammatory cytokines in saliva were similar to controls and gingival inflammation did not influence the concentration of inflammatory cytokines.