Estudo comparativo dos efeitos analgésicos do uso de Ibuprofeno/Oxicodona versus Ibuprofeno/Paracetamol em cirurgia de extração de terceiros molares inferiores: ensaio clínico triplo cego randomizado

Abstract

Regardless of the degree of complexity, after any surgical procedure, inflammatory mediators are released, triggering an inflammatory response and sensitizing local nerve endings. In this triple-blind, randomized, split-mouth clinical trial, 18 patients were evaluated in the postoperative impacted third molars extraction period, using the following parameters: trismus, pain, alveolitis and adverse effects (nausea, difficulty breathing, dizziness and constipation). Trismus was assessed on the seventh day after surgery, by measuring the maximum mouth opening in millimeters. The assessment of pain and adverse effects was carried out using a visual and numerical analogue scale and a report completed by the patient. The general aim of this work is to compare, through a split-mouth triple-blind randomized clinical trial, pharmacodynamically different analgesic medications (ibuprofen, oxycodone and paracetamol), and their effects in the postoperative period of impacted lower third molar extraction.