Relação entre os dados demográficos, clínicos, perfil inflamatório e desfechos fetais em mulheres com Diabetes Gestacional

Abstract

The aim of this study was to evaluate the correlation between demographic, clinical data, inflammatory profile and fetal outcomes in women with Gestational Diabetes. In this study, the sera of 180 pregnant women were evaluated from the retrospective study database carried out by Negrato et al. in an observational, cross-sectional study from April 2004 to November 2005 in Bauru, São Paulo, Brazil. Non-diabetic women with single pregnancies were randomly invited to participate. Patients with a diagnosis of GDM belonging to the high-risk gestation clinic were also invited. At 24-28th weeks of gestation a 100 g OGTT (oral glucose tolerance test) was performed. C- reactive protein (CRP), interleukin 6 (IL- 6), tumor necrosis factor alfa (TNF-alfa) and Glycated Hemoglobin (HbA1c) levels were measured at this moment. 176 patients were included in the study. No difference was found in IL-6, TNF-alpha and CRP serum levels in women with or without gestational diabetes. Multivariate analysis demonstrated that HbA1c, age, body mass index and history of previous Gestational Diabetes were independent predictors for gestational diabetes. The ROC curve indicated that values of HbA1C ≥ 5.1% were also predictive of gestational diabetes. Multivariate analysis showed that placental weight was a significant independent predictor (p <0.005) for the presence of adverse perinatal outcomes with a cut-off value of 610 grams as demonstrated by ROC curve