Investigação de nefropatia na psoríase moderada e grave através da pesquisa de microalbuminúria

Abstract

This study aims to evaluate the presence of early renal involvement in moderate to severe psoriasis, with or without psoriatic arthritis, through serum and urinary laboratory tests. The specific objectives of the study were: evaluate the presence of microalbuminuria, evaluate the serum creatinine value and evaluate the creatinine clearance value. The study in question is justified in terms of contributing to the search and expansion of scientific data that allow the assessment of the controversial association between renal involvement and psoriasis through the measurement of microalbuminuria as a routine instrument in laboratory investigation. A cross-sectional study was carried out on the population with psoriasis at the immunosuppressant and immunobiological outpatient clinic of the Dermatology Service of the Hospital Universitário Pedro Ernesto and the private medical office of the Institute of Dermatology and Aesthetics of Rio de Janeiro during the years 2018 to 2023. In this study 142 patients with moderate to severe plaque psoriasis associated or not with psoriatic arthritis underwent medical consultation, from which 60 patients were selected. Urinary and blood laboratory tests were then requested. After analyzing the data, only three female patients presented microalbuminuria using the urinary spot as a laboratory tool. Two of these patients presented grade II obesity and only one overweight according to the BMI calculation and classification. The presence of hypertension and diabetes was observed in only one of the patients with microalbuminuria. None of the three patients were using current nephrotoxic medications to treat psoriasis, but three patients used methotrexate or cyclosporine as prior treatment for psoriasis. It is important to mention that none of the three patients presented altered creatinine clearance and/or altered serum creatinine.