Avaliação histomorfétrica do corpo cavernoso após o tratamento com a dutasterida e a finasterida em um modelo roedor de hiperplasia prostática benigna

Abstract

Erectile dysfunction is a common adverse effect of treatment with finasteride and dutasteride for benign prostatic hyperplasia (BPH). However, it is not known what happens in the morphology of the corpus cavernosum after treatment with these drugs. The aim of this study was to investigate structural changes in the penis of a BPH model treated with dutasteride or finasteride. Sixty adult male rats were divided into the following groups: Ctrl, untreated Wistar Kyoto rats; Ctrl+D, Wistar Kyoto rats receiving dutasteride; Ctrl+F, Wistar Kyoto rats receiving finasteride; HPB, untreated spontaneously hypertensive rats (SHR); HPB+D, dutasteride treated SHR; and HPB+F, SHR treated with finasteride. All treatments were performed for 40 days, after treatment the penises were collected. The cavernous bodies were analyzed using histomorphometric methods to obtain the transverse penile area and the superficial density (Sv) of the smooth muscle fibers, connective tissue, fibers of the elastic system and sinusoidal spaces. The results were compared through one-way ANOVA with the Bonferroni post-test, considering p <0.05 as significant. The Ctrl+D and Ctrl+F groups showed significant reductions in the penile area, but increased the Sv of the elastic system fibers compared to the Ctrl group. The Ctrl+D group showed a reduction of Sv of the smooth muscle. The HPB group had a higher Sv of connective tissue, but the Sv of the sinusoidal space was lower in comparison to the Ctrl group. The HPB+D and HPB+F groups showed a reduction in Sv smooth muscle when compared to the group of BPH. In addition, the HPB+D group increased the Sv of connective tissue and Sv of the fibers of the elastic system compared to the HPB group. Both dutasteride and finasteride promoted penile modifications when compared to control and HPB groups, although these were more prominent in HPB animals. Dutasteride was the drug that most affected the cavernous body in this model of rodents.