Os efeitos adversos da dutasterida e tansulosina na histoarquitetura do pênis e dos rins de ratos

Abstract

Dutasteride is a drug used in the treatment of benign prostatic hyperplasia, however, the use of this medication can generate adverse effects. The combined treatment of dutasteride with tamsulosin has been shown to mitigate such adverse effects. However, we still do not know whether the combined treatment (dutasteride and tamsulosin) generates adverse effects or whether it preserves the histoarchitecture of the penis and kidneys. The aim of this study is to investigate whether the use of dutasteride, tamsulosin and the combined treatment (dutasteride and tamsulosin) can alter penile and renal morphology. 40 male rats with 90 days of life were used. The animals were divided into four groups, each with 10 animals: Ctrl group, composed of control rats; Dut group, composed of rats treated with dutasteride (0.5 mg/kg/day); Tam group, composed of rats treated with tamsulosin (0.4 mg/kg/day); CombAT group, composed of rats treated with dutasteride (0.5 mg/kg/day) and tamsulosin 0.4 mg/kg/day). All animals underwent oral treatment for 40 days. After this period, the animals were killed and the penis and kidneys were collected and processed for histomorphometric and stereological analysis. The CombAT group showed more alterations in the histoarchitecture of the corpus cavernosum (connective tissue, smooth muscle and sinusoid) than the animals in the Dut and Tam groups. In the Tam group, we also identified alterations in the morphology of the penis, although these alterations were smaller than in the animals of the CombAT and Dut groups. Significant changes in renal morphology were also identified, we highlight a reduction in glomerular volume in the animals of the Dut and CombAT groups. The Tam group also showed changes in glomerular volume, however, this change was smaller. The Dut, CombAT and Tam groups showed considerable loss of glomeruli. The Dut group showed greater renal damage than the Tam and CombAT groups. The combined treatment (CombAT) altered more the histoarchitecture of the rat's penis, such alterations may affect the erectile function of the rodents. In the kidneys, the combined treatment did not preserve the renal morphology, generating a considerable loss of glomeruli.