Síntese de fosfatos de cálcio ferro substituídos a partir da casca do ovo da galinha, candidatos a substitutos ósseos

Abstract

Throughout the aging process, it is natural for numerous diseases to affect humans. In this sense, there will naturally be an increase in the prevalence of musculoskeletal diseases. Both the health technology industry and academy must monitor this process so that better technologies can reach the population at more affordable prices. In this sense, with the increase in life expectancy of the world's population predicted for the coming decades, technological monitoring in the health area is necessary to support this demand. Considering the universe of musculoskeletal injuries, bone loss can complicate the prognosis of the treatment of injuries because it hinders the consolidation of bone tissue. Therefore, the use of biomaterials designed as synthetic substitutes for bone tissue, to meet the indications and profile of specific patients, can be an alternative to treatments with autologous grafting, considering the consequences of this type of treatment. Therefore, this work aims to develop a bone substitute from chicken eggshells and with a defined formulation, in order to obtain chemical-biological properties close to those of autologous bone grafts. During the experimental stage, different groups of calcium phosphates were produced, using chicken eggshells as a source of calcium ions, replaced with Fe3+ (0.5%, 1%, 2%, 3%, 4%, 5%, mol%). After the characterization steps (XRD, FTIR, SEM, XPS, Raman) and biological tests (cytotoxicity), favorable responses related to cell viability were observed for the syntheses containing lower concentrations of Fe3+ ions. Therefore, future formulation steps with these groups will define the viable candidates for in vivo tests.