Polifenóis da própolis: uma estratégia nutricional sobre o reparo tecidual cutâneo

Abstract

Propolis is a resinous substance rich in polyphenols and extensively used in alternative medicine. The same is produced by bees Apis mellifera species, in order to protect their hives against the action of other insects, many infectious agents or other external aggressors. Among the diverse species of propolis highlight the Brazilian red propolis in which the botanical origin was identified as Dalbergia ecastophyllum popularly known as monkey-tail, coming from the State of Alagoas. The propolis is rich in phenolic compounds, and various biological effects are attributed to the composition of potentially beneficial compounds to health. The objective of this study was to evaluate the effects of the polyphenols of red propolis (PPV) in the skin repair process in mice tissue repair. Swiss mice (18) mice were subjected to total excising lesions using 8 mm biopsy punch on the shaved back. The animals were treated orally with daily doses of vehicle (2% hydroalcoholic solution of ethanol control group) or 100 mg/kg of PPV (P100 group) or 200 mg/kg of PPV (P200 group). At the end of the experiment it was observed that the group treated with 100 mg / kg / polyphenol day of propolis (PPV) showed improvement in tissue repair, improves the contraction of the injury, acceleration of the inflammatory phase evidenced by lower volume density inflammatory cells (p <0.05), except neutrophils per mm² (p <0.05), lower the protein expression of NF-κB, which agrees with the lowest levels of plasma producing cytokines (TGF-β, TNF-α and IL-6). The P200 group showed similar results to the control group. Based on these data, the oral treatment with polyphenols of Brazilian propolis at a dose of 100 mg/kg/day may represent a new approach to the treatment of cutaneous lesions modulating the inflammatory response in a murine model of tissue repair