Planejamento e otimização de experimentos: planejamento fatorial 2³ aplicado em caracterização de ferro em fármacos

Abstract

This work looks for planning and optimization of previous experiments of characterization of iron in anemia medicine with ferrous sulphate, through factorial planning 2³. The factorial planning reduces the amount of tests needed to detect the influence of 2 or more factors in an experiment. In previous works from the research group, the objective was to estimate the presence of iron in anemia medicine, through x-ray fluorescence. This work showed the influence of the granulometry, the concentration of ferrous sulphate and the excipient used on these tests. The concentration of the drug was the main influencer of the tests, the granulometry of the sample showed minimun influence, being 4 times less than the concentration, this small influence was probably due to better distribution of the mix in the tablets made with the smaller granulometry, while the excipient was inert as expected.