Comparação de diferentes protocolos de exercício físico agudo na atividade microbicida de macrófagos: Leishmania major como modelo experimental

Abstract

Exercise can bring health benefits through responses and adaptations promoted in various biological systems, including the immune system. Moderate intensity exercise can reduce the risk of infection by intracellular microorganisms by directing the immune response to a Th1 type pattern. Strenuous physical exercise can lead to immune cell targeting, causing an immune window that can make the body susceptible to infection through the prevalence of a Th2-type response. This study investigates the effect of a single exercise session, acute, moderate or strenuous, on nitric oxide production by peritoneal macrophages of Balb / C mice. The mice were divided into 3 groups for acute exercise (sedentary control, moderate exercise and strenuous exercise). The acute exercise consisted of a single moderate session and a single strenuous session. A single session of moderate (acute) exercise promoted a significant increase in NO production in LPS-stimulated macrophages infected with Leishmania major or Leishmania braziliensis. A single session of moderate and strenuous exercise promoted a decrease in the Leishmania / Macrophage association index in in vitro Leishmania major and Leishmania braziliensis infection. These data suggest that acute exercise promotes an improvement in macrophage microbicidal capacity, which facilitates the resolution of infections by intracellular microorganisms, but further studies are needed to better understand such mechanisms