Frequência de HLADQ e IgAantitransglutaminase em crianças com Artrite Idiopática Juvenil

Abstract

Juvenile Idiopathic Arthritis (JIA) comprises a group of genetically related heterogeneous diseases whose common characteristic is the presence of chronic arthritis, and its association with other autoimmune diseases is common. Some studies show the association between JIA and celiac disease (CD). The aim is to evaluate the association between genetic and immunologic markers of CD in patients with JIA. We analyzed children and adolescents diagnosed with JIA seen in two university hospitals. Clinical data on symptoms suggestive of CD were collected and blood was collected for HLA - DQ, total IgA and anti - transglutaminase IgA. As a control group, adult bone marrow donors were used. Fifty seven patients (median age = 13, 50.9% female) and 71 controls (median age = 27, 76.5% female) were evaluated. Anti-transglutaminase IgA was positive in three controls and no patient [OR: 0.95; 95% IC 0.91-1.00; p = 0.25). Typical or intestinal symptoms (vomiting, abdominal pain and anorexia) and non-typical or extraintestinal symptoms (asthenia, anemia and numbness) were significantly higher among patients. The prevalence of HLA DQ2.5 and HLA-DQ8 did not differ between the two study groups [OR 1.07; CI 0.30-4.03 and OR 0.87; CI 0.33-2.31 respectively], whereas HLA-DQ2.2 was more prevalent among controls [OR 2.63; CI 1.00-7.50; p = 0.024). There was no significant difference in the prevalence of IgAtTG and HLA DQ2.5, high risk and HLA DQ8, of medium risk for CD, between the two study groups. However, HLA-DQ2.2, low risk for CD, was more prevalent in controls. Studies with greater sampling are necessary to better evaluate the association of JIA and these markers, since this increase may represent only the prevalence in the general population.