Staphylococcus aureus resistente a meticilina: impacto clínico em pacientes com fibrose cística acompanhados em centro de referência no Rio de Janeiro

Abstract

MRSA infection prevalence in CF patients has increased over the past decade. Information that portrays the conditions of the respiratory system and progression of lung structural lesions are needed among MRSA patients. The aim was to evaluate the clinical and tomographic impact of chronic MRSA infection and compare data with a control group chronically colonized by methicilin susceptible Staphylococcus aureus (MSSA). In this case-control study, each patient was evaluated for BMI, spirometric parameters and modified Bhalla score values for HRCT at chronic colonization moment with MRSA and MSSA and throughout the study period. Twenty case-control pairs were included. There were no significant differences between groups regarding BMI or BMI percentile at the moment of chronic MRSA colonization or for annual rate of change. Spirometric data showed a trend towards worse outcome in MRSA group. MRSA patients presented more severe and marked progression of lung disease, demonstrated by modified Bhalla score total value and all its parameters individually. MRSA chronic colonized patients present more functional and structural lung damage at the moment of chronic colonization and disease progression seems to be faster. This was shown through case-control comparison with control for potential confounding variables.